<\/span> <\/p>\n
\u3000\u30005\u670824\u65e5\uff0c\u541b\u5b9e\u751f\u7269<\/span><\/span>\u516c\u544a\u79f0\uff0c\u63a7\u80a1\u5b50\u516c\u53f8\u541b\u62d3\u751f\u7269\u4e0e\u65fa\u5c71\u65fa\u6c34\u5408\u4f5c\u5f00\u53d1\u53e3\u670d\u6838\u82f7\u7c7b\u6297\u65b0\u51a0\u75c5\u6bd2\u836f\u7269VV116\u7247\uff08\u4ec1\u660e\u5fb7\u97e6\uff09\uff0c\u5728\u4e00\u9879\u5bf9\u6bd4\u5948\u739b\u7279\u97e6\u7247\/\u5229\u6258\u90a3\u97e6\u7247\uff08\u5373\u8f89\u745e\u65b0\u51a0\u53e3\u670d\u836fPAXLOVID\uff09\u7528\u4e8e\u8f7b\u4e2d\u5ea6\u65b0\u51a0\u80ba\u708e\u65e9\u671f\u6cbb\u7597\u7684III\u671f\u6ce8\u518c\u4e34\u5e8a\u7814\u7a76\uff08NCT05341609\uff09\u4e2d\uff0c\u8fbe\u5230\u65b9\u6848\u9884\u8bbe\u7684\u4e3b\u8981\u7ec8\u70b9\uff1b\u541b\u5b9e\u751f\u7269\u5c06\u4e8e\u8fd1\u671f\u4e0e\u76d1\u7ba1\u90e8\u95e8\u6c9f\u901a\u9012\u4ea4\u8be5\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u4e8b\u5b9c\u3002<\/p>\n \u3000\u3000\u8fd9\u4e5f\u610f\u5473\u7740\uff0cVV116\u4e0e\u8f89\u745ePAXLOVID\u7528\u4e8e\u6cbb\u7597\u8f7b\u5ea6\u81f3\u4e2d\u5ea6\u65b0\u51a0\u75c5\u6bd2\u611f\u67d3\u8005\u7684\u5934\u5bf9\u5934\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u5df2\u51fa\u7089\u3002\u867d\u7136\u541b\u5b9e\u751f\u7269\u5c1a\u672a\u62ab\u9732\u5177\u4f53\u7684\u4e34\u5e8a\u6570\u636e\uff0c\u4f46\u6839\u636e\u8fbe\u5230\u201c\u4e3b\u8981\u7ec8\u70b9\u201d\u8fd9\u4e00\u7ed3\u8bba\uff0c\u53ef\u8bf4\u660e\u5728\u672c\u7814\u7a76\u6240\u8bbe\u7f6e\u7684\u6807\u51c6\u4e0a\uff0cVV116\u7247\u5728\u7597\u6548\u4e0a\u81f3\u5c11\u4e0d\u5dee\u4e8ePAXLOVID\uff08\u975e\u52a3\uff09\u3002<\/p>\n \u3000\u3000\u4e8c\u7ea7\u5e02\u573a\u4e0a\uff0c5\u670824\u65e5\u541b\u5b9e\u751f\u7269\u80a1\u4ef7\u51fa\u73b0\u4e0b\u8dcc\u3002\u622a\u81f3\u53d1\u7a3f\u65f6\uff0c\u6e2f\u80a1\u8dcc\u8d8510%\uff1bA\u80a1\u8dcc\u8d8516%\u3002<\/p>\n \u3000\u3000VV116\uff08\u4ec1\u660e\u5fb7\u97e6\uff09\u662f\u4e00\u7c7b\u53e3\u670d\u6838\u82f7\u7c7b\u6297\u65b0\u51a0\u75c5\u6bd2\u836f\u7269\uff0c\u539f\u7406\u662f\u901a\u8fc7\u9776\u5411RNA\u4f9d\u8d56\u7684RNA\u805a\u5408\u9176\uff08RdRp\uff09\u6291\u5236\u75c5\u6bd2RNA\u5408\u6210\u3002\u5176\u7531\u4e2d\u56fd\u79d1\u5b66\u9662\u4e0a\u6d77\u836f\u7269\u7814\u7a76\u6240\u3001\u4e2d\u56fd\u79d1\u5b66\u9662\u6b66\u6c49\u75c5\u6bd2\u7814\u7a76\u6240\u3001\u4e2d\u56fd\u79d1\u5b66\u9662\u65b0\u7586\u7406\u5316\u6280\u672f\u7814\u7a76\u6240\u3001\u65fa\u5c71\u65fa\u6c34\u3001\u4e2d\u56fd\u79d1\u5b66\u9662\u4e2d\u4e9a\u836f\u7269\u7814\u53d1\u4e2d\u5fc3\u5171\u540c\u7814\u53d1\u30022021\u5e749\u6708\uff0c\u541b\u5b9e\u751f\u7269\u5ba3\u5e03\u4e0e\u65fa\u5c71\u65fa\u6c34\u8fbe\u6210\u5408\u4f5c\uff0c\u5171\u540c\u627f\u62c5\u8be5\u836f\u7269\u5728\u5168\u7403\u8303\u56f4\u5185\u7684\u4e34\u5e8a\u5f00\u53d1\u548c\u4ea7\u4e1a\u5316\u5de5\u4f5c\u3002<\/p>\n \u3000\u3000NCT05341609\u7814\u7a76\u662f\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u5355\u76f2\u3001\u968f\u673a\u3001\u5bf9\u7167III\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u7531\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u745e\u91d1\u533b\u9662\u5b81\u5149\u9662\u58eb\u62c5\u4efb\u4e3b\u8981\u7814\u7a76\u8005\uff0c\u5b9e\u9645\u5165\u7ec4822\u4f8b\u60a3\u8005\uff0c\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\u4e3a\u201c\u81f3\u6301\u7eed\u4e34\u5e8a\u6062\u590d\u7684\u65f6\u95f4\u201d\uff0c\u6b21\u8981\u7814\u7a76\u7ec8\u70b9\u5305\u62ec\u201c\u622a\u81f3\u7b2c28\u5929\u53d1\u751f\u65b0\u51a0\u8fdb\u5c55\uff08\u5b9a\u4e49\u4e3a\u8fdb\u5c55\u4e3a\u91cd\u5ea6\/\u5371\u91cd\u6216\u5168\u56e0\u6b7b\u4ea1\uff09\u7684\u53d7\u8bd5\u8005\u767e\u5206\u6bd4\u201d\u7b49\u3002\u800c\u5934\u5bf9\u5934\u5373\u4e3aVV116\u4e0e\u8f89\u745ePAXLOVID\u76f4\u63a5\u5bf9\u6bd4\u7597\u6548\u3002<\/p>\n \u3000\u3000\u201c\u81f3\u6301\u7eed\u4e34\u5e8a\u6062\u590d\u65f6\u95f4\u201d\u8fd9\u4e00\u4e34\u5e8a\u7ec8\u70b9\u901a\u4fd7\u6765\u8bb2\uff0c\u5c31\u662f\u53d7\u8bd5\u8005\u7684\u65b0\u51a0\u75c5\u6bd2\u8f6c\u9634\u65f6\u95f4\uff082\u6b21\u6838\u9178\u68c0\u6d4b\u9634\u6027\u53ca\u76f8\u5e94\u7684\u75c7\u72b6\u8bc4\u5206\u8fbe\u5230\u6062\u590d\u7b49\u7ea7\uff09\uff0c\u4eca\u5e745\u670818\u65e5\uff0cVV116\u5728\u4e2d\u56fd\u5965\u5bc6\u514b\u620e\u611f\u67d3\u53d7\u8bd5\u8005\u4e2d\u7684\u9996\u4e2a\u4e34\u5e8a\u7814\u7a76\u5728\u300aEmerging Microbes & Infections\u300b\u6742\u5fd7\u4e0a\u53d1\u5e03\u3002\u7814\u7a76\u663e\u793a\uff0c\u63a5\u53d7VV116\u6cbb\u7597\u60a3\u8005\u7684\u65b0\u51a0\u75c5\u6bd2\u8131\u843d\u65f6\u95f4\uff08\u6838\u9178\u8f6c\u9634\u65f6\u95f4\uff09\u8981\u66f4\u77ed\u3002<\/p>\n \u3000\u3000\u800c\u968f\u7740\u4ec1\u660e\u5fb7\u97e6\u79ef\u6781\u7684\u7814\u7a76\u7ed3\u679c\u4e0d\u65ad\u516c\u5e03\uff0c\u5176\u4e5f\u5f00\u59cb\u88ab\u4e00\u4e9b\u7f51\u53cb\u79f0\u4f5c\u201c\u4eba\u6c11\u5fb7\u97e6\u201d\u3002<\/p>\n \u3000\u3000\u636e\u4e2d\u56fd\u4e34\u5e8a\u8bd5\u9a8c\u6ce8\u518c\u4e2d\u5fc3\u663e\u793a\uff0c\u672c\u6b21\u5934\u5bf9\u5934\u8bd5\u9a8c\u7684\u6cbb\u7597\u65b9\u6848\u4e3a\uff1a\u8bd5\u9a8c\u7ec4\uff08VV116\u7ec4\uff09\u4e2d\uff0c\u53d7\u8bd5\u8005\u5c06\u5728\u7b2c1\u5929\u63a5\u53d7\u6bcf12\u5c0f\u65f6600 mg VV116\u3001\u7b2c2-5\u5929\u63a5\u53d7\u6bcf12\u5c0f\u65f6300 mg VV116\u53e3\u670d\u6cbb\u7597\uff1b\u5bf9\u7167\u7ec4\uff08Paxlovid\u7ec4\uff09\uff0c\u53d7\u8bd5\u8005\u5c06\u5728\u7b2c1-5\u5929\u5747\u63a5\u53d7\u6bcf12\u5c0f\u65f6\u5948\u739b\u7279\u97e6\u7247300mg+\u5229\u6258\u90a3\u97e6\u7247100mg\u7684\u53e3\u670d\u6cbb\u7597\u3002<\/p>\n \u3000\u3000\u8be5\u8bd5\u9a8c\u7684\u7eb3\u5165\u6807\u51c6\u63d0\u793a\uff0c\u53d7\u8bd5\u8005\u5fc5\u987b\u4e3a18\u5c81\u53ca\u4ee5\u4e0a\u7684\u65b0\u51a0\u75c5\u6bd2\u9633\u6027\u611f\u67d3\u8005\uff1b\u5177\u6709\u4e00\u4e2a\u6216\u591a\u4e2a\u8f7b\u5ea6\u6216\u4e2d\u5ea6\u65b0\u51a0\u4e34\u5e8a\u75c7\u72b6\uff0c\u4f8b\u5982\uff1a\u53d1\u70ed\uff0c\u54b3\u55fd\uff0c\u54bd\u5589\u75db\uff0c\u9f3b\u585e\u6216\u8005\u6d41\u9f3b\u6d95\uff0c\u5934\u75db\uff0c\u808c\u8089\u75db\uff0c\u6076\u5fc3\uff0c\u5455\u5410\uff0c\u8179\u6cfb\uff0c\u6c14\u4fc3\u6216\u8005\u547c\u5438\u56f0\u96be\uff0c\u754f\u5bd2\u6216\u8005\u5bd2\u6218\u3002<\/p>\n \u3000\u3000\u7531\u4e8e\u662f\u4e00\u9879\u65b0\u51a0\u80ba\u708e\u65e9\u671f\u6cbb\u7597\u7684\u7814\u7a76\uff0c\u7814\u7a76\u65b9\u6848\u63d0\u793a\uff0c\u53d7\u8bd5\u8005\u9700\u6ee1\u8db3\u4e0b\u8ff0\u6761\u4ef6\u4e2d\u7684\u4e00\u9879\u6216\u591a\u9879\u6761\u4ef6\uff1a\u5728\u6d4b\u5b9a\u9633\u6027\u611f\u67d3\u7ed3\u679c\u76847\u65e5\u5185\u8fdb\u884c\u9996\u6b21\u7ed9\u836f\uff1b\u9996\u6b21\u7ed9\u836f\u5f53\u65e5\u65b0\u51a0\u75c5\u6bd2\u6838\u9178\u68c0\u6d4bCt\u503c\u226420\uff1b\u5728\u9996\u6b21\u7ed9\u836f\u76845\u65e5\u5185\u5c31\u51fa\u73b0\u65b0\u51a0\u75c7\u72b6\u3002<\/p>\n \u3000\u3000\u8003\u8651\u5230\u8bd5\u9a8c\u5305\u542b\u91cd\u75c7\u8fdb\u5c55\u60c5\u51b5\u76d1\u6d4b\u7b49\u56e0\u7d20\uff0c\u53d7\u8bd5\u9a8c\u8005\u8fd8\u9700\u6ee1\u8db3\u4e0b\u8ff0\u4e00\u9879\u6216\u591a\u9879\u8fdb\u5c55\u4e3a\u91cd\u5ea6\u7684\u9ad8\u98ce\u9669\u56e0\u7d20\uff0c\u5305\u62ec\uff1a\u5e74\u9f84\u572860\u5c81\u53ca\u4ee5\u4e0a\uff1b\u60a3\u6709\u5fc3\u8840\u7ba1\u75be\u75c5\uff08\u5305\u62ec\u5148\u5929\u6027\u5fc3\u810f\u75c5\uff09\u6216\u9ad8\u8840\u538b\uff1b\u60a3\u6709\u6162\u6027\u80ba\u75c5\uff08\u4f8b\u5982\u6162\u6027\u963b\u585e\u6027\u80ba\u75be\u75c5\u3001\u4e2d\u91cd\u5ea6\u54ee\u5598\u3001\u95f4\u8d28\u6027\u80ba\u75be\u75c5\u3001\u56ca\u6027\u7ea4\u7ef4\u5316\u548c\u80ba\u52a8\u8109\u9ad8\u538b\uff1b\u60a3\u6709\u7cd6\u5c3f\u75c5\uff1b\u5b58\u5728\u514d\u75ab\u6291\u5236\u75be\u75c5\u6216\u6b63\u5728\u63a5\u53d7\u514d\u75ab\u6291\u5236\u6cbb\u7597\uff08\u4f8b\u5982\u957f\u671f\u4f7f\u7528\u76ae\u8d28\u7c7b\u56fa\u9187\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u836f\u7269\u5bfc\u81f4\u514d\u75ab\u529f\u80fd\u4e0b\u964d\uff09\u7b4913\u9879\u98ce\u9669\u56e0\u7d20\u3002<\/p>\n \u3000\u3000\u4e2d\u56fd\u4e34\u5e8a\u8bd5\u9a8c\u6ce8\u518c\u4e2d\u5fc3\u4fe1\u606f\u8fd8\u663e\u793a\uff0c\u8be5\u8bd5\u9a8c\u7684\u6b21\u8981\u6307\u6807\u8fd8\u5305\u62ec\uff1a\u7b2c3\u30015\u30017\u300110\u300114\u300121\u548c28\u5929\uff0c\u4e34\u5e8a\u75c7\u72b6\u6d88\u5931\u7684\u53d7\u8bd5\u8005\u767e\u5206\u6bd4\uff1b\u4ece\u57fa\u7ebf\u5230\u7b2c3\u30015\u30017\u300110\u300114\u300121\u548c28\u5929\uff0c\u65b0\u51a0\u75c7\u72b6\u8bc4\u5206\u7684\u53d8\u5316\uff1b\u4ece\u57fa\u7ebf\u5230\u7b2c3\u30015\u30017\u300110\u300114\u300121\u548c28\u5929\uff0cWHO\u4e34\u5e8a\u8fdb\u5c55\u91cf\u8868\u7684\u53d8\u5316\uff1b\u7b2c3\u30015\u30017\u300110\u300114\u5929\u65b0\u51a0\u75c5\u6bd2\u8f6c\u9634\u7684\u53d7\u8bd5\u8005\u767e\u5206\u6bd4\uff1b\u7b2c3\u30015\u30017\u300110\u300114\u5929Ct\u503c\u8f83\u57fa\u7ebf\u7684\u53d8\u5316\u7b49\u7b49\u3002\u4e0e\u4e3b\u8981\u7ec8\u70b9\u6062\u590d\u65f6\u95f4\u76f8\u6bd4\uff0c\u8be5\u8bd5\u9a8c\u7684\u4f17\u591a\u6b21\u8981\u7ec8\u70b9\u66f4\u80fd\u4f53\u73b0\u51fa\u53d7\u8bd5\u8005\u5728\u7528\u836f\u540e\u53d1\u751f\u7684\u5177\u4f53\u53d8\u5316\u3002\u4e0d\u8fc7\uff0c\u5728\u5f53\u524d\u516c\u544a\u4e2d\uff0c\u8fd9\u4e00\u7cfb\u5217\u4fe1\u606f\u5747\u6682\u65e0\u62ab\u9732\u3002<\/p>\n 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